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CHEM-4300: Medicinal Chemistry
</title>
<meta property="og:title" content="CHEM-4300: Medicinal Chemistry">
<meta property="og:description" content="This course explores the fundamental principles that define the relationship between chemical structure and the biological action of drug molecules. A major focus of the course is the application of these chemical principles to molecular-targeted drug discovery, molecular mechanisms of pharmacological activity, and the biopharmaceutical properties of drugs. The relationships between drug structure, therapeutic properties, and physicochemical characteristics will be discussed. Structure activity relationships (SAR), structure-property relationships (SPR) and ADME (absorption, distribution, metabolism, and excretion) will be explored and presented through case studies. The roles of computational chemistry, molecular modeling, and biophysical methods in the understanding of the relationship between structure and biological activity will also be studied. Although an emphasis will be placed on orally bioavailable small molecules, alternative drug modalities will also be discussed.">
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<h1 id="name">
Medicinal Chemistry
</h1>
<h2 id="code">
CHEM-4300
</h2>
<p>
This course explores the fundamental principles that define the relationship between chemical structure and the biological action of drug molecules. A major focus of the course is the application of these chemical principles to molecular-targeted drug discovery, molecular mechanisms of pharmacological activity, and the biopharmaceutical properties of drugs. The relationships between drug structure, therapeutic properties, and physicochemical characteristics will be discussed. Structure activity relationships (SAR), structure-property relationships (SPR) and ADME (absorption, distribution, metabolism, and excretion) will be explored and presented through case studies. The roles of computational chemistry, molecular modeling, and biophysical methods in the understanding of the relationship between structure and biological activity will also be studied. Although an emphasis will be placed on orally bioavailable small molecules, alternative drug modalities will also be discussed.
</p>
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<span id="credits-pill" class="attr-pill">
3 credits
</span>
</div>
<div id="crosslist-container">
<div id="crosslist-title" class="rel-info-title">
Cross-listed with:
</div>
<div id=crosslist-classes" class="rel-info-courses">
<a class="course-pill" href="CHEM-6300">CHEM-6300 Medicinal Chemistry</a>
</div>
</div>
<div id="prereq-container" class="rel-info-container">
<div id="prereq-title" class="rel-info-title">
Prereqs:
</div>
<div id="prereq-classes" class="rel-info-courses">
<a class="course-pill" href="CHEM-2260">CHEM-2260 Organic Chemistry II</a>
</div>
</div>
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Past Term Data
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Not Offered
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Offered as Cross-Listing Only
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Detailed View
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</div>
<table id="years-table">
<thead>
<tr>
<th></th>
<th class="spring season-label">Spring</th>
<th class="summer season-label" colspan="2">Summer</th>
<th class="fall season-label">Fall</th>
</tr>
<tr>
<th colspan="2"></th>
<th class="summer2 midsum-label">(Session 1)</th>
<th class="summer3 midsum-label">(Session 2)</th>
<th></th>
</tr>
</thead>
<tbody>
<tr>
<th class="year">2024</th>
<td class="term spring offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=202401&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (3c)</a>
</span>
<ul class="prof-list">
<li>Christopher Lawrence Cioffi</li>
</ul>
<span class="course-capacity">
Seats Taken: 4/20
</span>
</div>
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=202409&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (3c)</a>
</span>
<ul class="prof-list">
<li>Christopher Lawrence Cioffi</li>
</ul>
<span class="course-capacity">
Seats Taken: 0/20
</span>
</div>
</td>
</tr>
<tr>
<th class="year">2023</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2022</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2021</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2020</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2019</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2018</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2017</th>
<td class="term spring offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=201701&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Robert Jason Herr</li>
</ul>
<span class="course-capacity">
Seats Taken: 0/25
</span>
</div>
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2016</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2015</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2014</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=201409&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 19/25
</span>
</div>
</td>
</tr>
<tr>
<th class="year">2013</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=201309&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 18/30
</span>
</div>
</td>
</tr>
<tr>
<th class="year">2012</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=201209&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 22/30
</span>
</div>
</td>
</tr>
<tr>
<th class="year">2011</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=201109&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 19/30
</span>
</div>
</td>
</tr>
<tr>
<th class="year">2010</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=201009&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 32/25
</span>
</div>
</td>
</tr>
<tr>
<th class="year">2009</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=200909&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 10/25
</span>
</div>
</td>
</tr>
<tr>
<th class="year">2008</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2007</th>
<td class="term spring offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=200701&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 21/21
</span>
</div>
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2006</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2005</th>
<td class="term spring offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=200501&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 10/20
</span>
</div>
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2004</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2003</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2002</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2001</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">2000</th>
<td class="term spring not-offered">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=200009&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 18/40
</span>
</div>
</td>
</tr>
<tr>
<th class="year">1999</th>
<td class="term spring offered-diff-code">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall not-offered">
</td>
</tr>
<tr>
<th class="year">1998</th>
<td class="term spring unscheduled">
</td>
<td colspan="2" class="term summer not-offered">
</td>
<td class="term fall offered">
<div class="view-container detail-view-container">
<span class="term-course-info">
<a href="https://sis.rpi.edu/rss/bwckctlg.p_disp_listcrse?term_in=199809&subj_in=CHEM&crse_in=4300&schd_in=">Medicinal Chemistry (4c)</a>
</span>
<ul class="prof-list">
<li>Mark Wentland</li>
</ul>
<span class="course-capacity">
Seats Taken: 26/60
</span>
</div>
</td>
</tr>
</tbody>
</table>
</div>
</div>
</body>
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