This course covers the theory and practice of biological sequence analysis, including algorithms for pairwise sequence alignment, multiple sequence alignment, phylogenetic analysis, and database searching. Concepts covered include homology, sequence similarity, parsimony, mechanisms and metrics of molecular evolution, biological data bases, database search algorithms (BLAST), and statistical significance. Selected topics include hidden Markov models, bootstrap analysis, and gene finding. Modern sequence analysis software will be provided. Laptop computers are required. Knowledge of a programming language is strongly suggested. Meets jointly with BIOL 4540.
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