Muscle Mechanics and Modeling

BMED-6660

This graduate/advanced undergraduate hybrid course examines the structural and physiologic properties of muscle, as well as its force production and overall biomechanical function. Muscle structure and function will be explored at the protein, single fiber and whole tissue levels. Discussions will focus primarily on skeletal muscle, and topics will include muscle morphology, cross-bridge theory, molecular motor and actomyosin interaction, Hill-type and Huxley-type models, electromyography, fatigue, muscle inhibition, history-dependent phenomena, in vitro and in vivo muscle function, and the response to injury. Each topic will be introduced and developed utilizing seminal articles in the literature as well as excerpts from texts, and further discussion on current problems and state-of-the-art experimental techniques will draw on the current scientific literature.

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