diff --git a/CMakeLists.txt b/CMakeLists.txt
index cd85c0b8bc..6e575323b3 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -379,6 +379,11 @@ endif()
 enable_testing()
 add_subdirectory(externals)
 
+# See externals/CMakeLists.txt
+foreach(def ${CRYPTOPP_COMPILE_DEFINITIONS})
+    add_definitions(-D${def})
+endforeach()
+
 # Boost
 if (USE_SYSTEM_BOOST)
     find_package(Boost 1.70.0 COMPONENTS serialization REQUIRED)
diff --git a/externals/CMakeLists.txt b/externals/CMakeLists.txt
index 3c290347a6..48bd2ac349 100644
--- a/externals/CMakeLists.txt
+++ b/externals/CMakeLists.txt
@@ -35,6 +35,12 @@ set(CRYPTOPP_INSTALL OFF)
 set(CRYPTOPP_SOURCES "${CMAKE_SOURCE_DIR}/externals/cryptopp")
 add_subdirectory(cryptopp-cmake)
 
+# HACK: Mismatch between compilation of CryptoPP and headers used in Citra can cause runtime issues.
+# Pull out the compile definitions from CryptoPP and apply them to Citra as well to fix this.
+# See: https://github.com/weidai11/cryptopp/issues/1191
+get_source_file_property(CRYPTOPP_COMPILE_DEFINITIONS ${CRYPTOPP_SOURCES}/cryptlib.cpp TARGET_DIRECTORY cryptopp COMPILE_DEFINITIONS)
+set(CRYPTOPP_COMPILE_DEFINITIONS ${CRYPTOPP_COMPILE_DEFINITIONS} PARENT_SCOPE)
+
 # HACK: The logic to set up the base include directory for CryptoPP does not work with Android SDK CMake 3.22.1.
 # Until there is a fixed version available, this code will detect and add in the proper include if it does not exist.
 if(ANDROID)